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KMID : 0380020080230020142
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Korean Journal of Biotechnology and Bioengineering
2008 Volume.23 No. 2 p.142 ~ p.146
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Effect of Mulberry Extracts on Secretion of MMPs and Plasmin in U-373-MG Cells
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Lee Suk-Hee
Kim Hwan-Gyu
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Abstract
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In order to sprout and migrate, cells must secrete proteinases which are degrading the surrounding extracellular matrix. In this study, we examined the effect of mulberry extracts and combination of mulberry extracts and VEGF on human malignant glioma U-373-MG cells. Mulberry extracts induced the secretion of matrix metalloproteinase-9 (MMP-9) and suppressed the secretion of MMP-2 and plasmin. Mulberry extracts inhibited the VEGF-induced MMP-2, MMP-9 and plasmin secretion. It is therefore, suggested that mulberry extracts can suppress the VEGF-induced tumor angiogenesis in U-373-MG cells. Also, mulberry extracts induced the secretion of MMP-9 and plasmin through PI 3’-kinase pathway in U-373-MG cells.
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KEYWORD
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Mulberry, MMP, plasmin, VEGF
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